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Cat No. | Product Name | Synonyms | Targets |
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T63790 | Cbl-b-IN-3 | E1/E2/E3 Enzyme | |
Cbl-b-IN-3 is a potent proto-oncogene-B (CPL-B) inhibitor of casitas B-series lymphoma (ic50 < 1 nM). Cpl-b, a cyclic E3 ubiquitin protein ligase, is involved in the setting of T lymphocyte activation thresholds. Cpl-b n... | |||
T11096 | DRI-C21045 | NF-κB | |
Dri-c21045 showed concentration-dependent inhibition of NF- B activation and all CD40L induced by B cell proliferation. IC50 was 17.1 M and 4.5 M, respectively.Dri-c21045 is an effective selective inhibitor of CD40-CD40L... | |||
T3705 | GDC0084 | GDC-0084,RG7666,GDC 0084 | PI3K , mTOR |
GDC0084 (RG7666) is a PI3K inhibitor with potential antineoplastic activity. GDC0084 (RG7666) specifically inhibits PI3K in the PI3K/AKT kinase (or protein kinase B) signaling pathway, thereby inhibiting the activation o... | |||
T68523 | AMG-628, (S)- | ||
AMG-628, (S)-, is the S isomer of AMG-628 --- a potent, ATP-competitive inhibitor of Raf kinases. AMG-628 displays selectivity for Raf kinases and inhibits activation of tyrosine protein kinases such as VEGFR2, Lyn, Flt1... | |||
T71736 | AMG-628, (R)- | ||
AMG-628, (R)- is the R isomer of AMG-628 --- a potent, ATP-competitive inhibitor of Raf kinases. AMG-628 displays selectivity for Raf kinases and inhibits activation of tyrosine protein kinases such as VEGFR2, Lyn, Flt1 ... | |||
T75104 | CD19 CAR circRNA | ||
CD19 CAR circRNA, expressing CD19 car protein, is utilized in chimeric antigen receptor T cell immunotherapy (CAR-CD19). This compound involves a chimeric antigen receptor, CD19, a CD molecule present on B cells (i.e., l... | |||
T78302 | Atacicept | TACI-Ig,TACI-Fc 5 | |
Atacicept (TACI-Ig), a recombinant fusion protein, comprises the extracellular, ligand-binding segment of the TACI receptor fused with the Fc portion of human IgG. It functions by inhibiting B cell activation through bin... | |||
T73093 | Z-VRPR-FMK | ||
Z-VRPR-FMK, an irreversible inhibitor of the MALT1 protein, effectively suppresses the proliferation and invasion of diffuse large B-cell lymphoma. This is achieved through the inhibition of MALT1-induced NF-κB activatio... | |||
T75103 | CD19 CAR mRNA | ||
CD19 CAR mRNA is designed to express the CD19 chimeric antigen receptor (CAR) protein, pivotal in chimeric antigen receptor T cell (CAR-CD19) immunotherapy. This receptor targets CD19, a membrane antigen crucial for B ce... | |||
T71188 | LY2780301 | ||
LY2780301 is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor LY2780301 binds to and inhibits the activity of Akt, which... | |||
T36034 | CAY10774 | ||
CAY10774 is an inhibitor of the protein-protein interaction between programmed cell death 1 (PD-1) and its ligand PD-L1 (IC50= 15 nM in a homologous time-resolved fret (HTRF) assay).1It increases the activation of Jurkat... | |||
T36046 | LH1306 | ||
LH1306 is an inhibitor of the interaction between programmed cell death 1 (PD-1) and its ligand PD-L1 that has an IC50 value of 25 nM in a homologous time-resolved fluorescence (HTRF) assay.1 It increases the activation ... | |||
T36047 | LH1307 | ||
LH1307 is an inhibitor of the interaction between programmed cell death 1 (PD-1) and its ligand PD-L1 that has an IC50 value of 3 nM in a homologous time-resolved fluorescence (HTRF) assay.1 It increases the activation o... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T6S1780 | Protosappanin B | Q-100961,FT-0689654 | Apoptosis |
1. Protosappanin B (Q-100961) significantly increases cell viability, inhibits cell apoptosis and up-regulates the expression of growth-associated protein 43. 2. Protosappanin B induces the degradation of p53 protein, vi... | |||
T5S2343 | Acetylshikonin | Acetyl shikonin | Others , P450 , AChE |
1. Acetylshikonin exhibits weak cytotoxicity against human umbilical vein endothelial cells (HUVECs) with IC5 of over 2 microM, exhibits the antiangiogenic and antitumorigenic effects by suppressing proliferation and ang... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-01070 | CD83 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
CD83 antigen is a single-pass type I membrane protein which contains one Ig-like V-type (immunoglobulin-like) domain. CD83 is expressed by activated lymphocytes, Langerhans cells and interdigitating reticulum cells. It c... | |||
TMPJ-01323 | NTAL Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Linker for Activation of T-Cells Family Member 2 (LAT2) is a single-pass type III membrane protein. LAT2 is highly expressed in the spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. LAT2 is invol... | |||
TMPY-01648 | TREML2 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Trem-like transcript 2 protein, also known as Triggering receptor expressed on myeloid cells-like protein 2, TREML2 and TLT2, is a single-pass type I membrane protein that contains one Ig-like V-type (immunoglobulin-like... | |||
TMPJ-00038 | IL-7 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
Mouse interleukin-7(IL-7) is the member of hemopoietin family which is important to the differentiation, proliferation, and survival of lymphocyte. Mouse IL-7 shares approximately 88% aa sequence identity with rat IL-7 a... | |||
TMPY-00817 | Granzyme B/GZMB Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Granzyme B, also known as GZMB, is the most prominent member of the granzyme family of cell death-inducing serine proteases expressed in the granules of cytotoxic T lymphocytes (CTLs) and NK cells. Granzyme B enters the ... | |||
TMPJ-00994 | LTBR Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
It is a single-pass type I membrane protein and contains 4 TNFR-Cys repeats. The protein is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including ce... | |||
TMPJ-00042 | TSLP Protein, Human, Recombinant | Human | E. coli |
Thymic stromal lymphopoietin (TSLP) is a novel member of the hemopoietic cytokine family that promotes the development of B cells and shares overlapping activity with IL-7. The human TSLP protein comprises a 28 amino aci... | |||
TMPY-02191 | BLNK Protein, Human, Recombinant (His) | Human | HEK293 Cells |
B-cell linker protein, also known as B-cell adapter containing a SH2 domain protein, B-cell adapter containing a Src homology 2 domain protein, Cytoplasmic adapter protein, Src homology 2 domain-containing leukocyte p... | |||
TMPH-02551 | CD20 Protein, Mouse, Recombinant (His) | Mouse | P. pastoris (Yeast) |
B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes. Functions as a store-operated calcium... | |||
TMPY-00361 | Pellino-1 Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells |
PELI is a family of E3 ubiquitin ligases that regulate protein activity through a post-translational modification, ubiquitination. PELI1 may function to control inadvertent activation of RIP3, thus preventing aberrant ce... | |||
TMPH-02208 | TRAF3 Protein, Human, Recombinant | Human | E. coli |
Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon.... | |||
TMPK-00302 | CD5 Protein, Human, Recombinant (hFc & Avi), Biotinylated | Human | HEK293 Cells |
CD5: a type I transmembrane protein found on T cells, thymocytes, and some B cells that is a ligand for CD72 and is involved in cellular activation or adhesion; expressed in B-cell chronic lymphocytic leukemia and T-cell... | |||
TMPK-00642 | CD5 Protein, Rhesus macaque, Recombinant (His & Avi) | Rhesus | HEK293 Cells |
CD5: a type I transmembrane protein found on T cells, thymocytes, and some B cells that is a ligand for CD72 and is involved in cellular activation or adhesion; expressed in B-cell chronic lymphocytic leukemia and T-cell... | |||
TMPH-00344 | CD20 Protein, Canine, Recombinant (His & Myc) | Canine | E. coli |
B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes. Functions as a store-operated calcium... | |||
TMPK-00301 | CD5 Protein, Human, Recombinant (hFc & Avi) | Human | HEK293 Cells |
CD5: a type I transmembrane protein found on T cells, thymocytes, and some B cells that is a ligand for CD72 and is involved in cellular activation or adhesion; expressed in B-cell chronic lymphocytic leukemia and T-cell... | |||
TMPK-00300 | CD5 Protein (Primary Amine Labeling), Mouse, Recombinant (His), Biotinylated | Mouse | HEK293 Cells |
CD5: a type I transmembrane protein found on T cells, thymocytes, and some B cells that is a ligand for CD72 and is involved in cellular activation or adhesion; expressed in B-cell chronic lymphocytic leukemia and T-cell... | |||
TMPK-00643 | CD5 Protein, Rhesus macaque, Recombinant (His & Avi), Biotinylated | Rhesus | HEK293 Cells |
CD5: a type I transmembrane protein found on T cells, thymocytes, and some B cells that is a ligand for CD72 and is involved in cellular activation or adhesion; expressed in B-cell chronic lymphocytic leukemia and T-cell... | |||
TMPK-00152 | CD27/TNFRSF7 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells |
CD27, also known as TNFRSF7, is an approximately 55 kDa transmembrane protein in the TNF receptor superfamily. It functions as a co‑stimulatory molecule that supports lymphocyte activation and survival. It binds to ligan... | |||
TMPH-02757 | LILRB3 Protein, Mouse, Recombinant (aa 25-642, His) | Mouse | HEK293 Cells |
May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosp... | |||
TMPJ-01365 | SLAMF8 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
SLAM family member 8 (SLAMF8) is a single-pass type I membrane protein and contains 1 Ig-like C2-type domain. SLAMF8 is a member of the CD2 family of cell surface proteins involved in lymphocyte activation. These protei... | |||
TMPH-02271 | BTK Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activatio... | |||
TMPK-00178 | B7-1 Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells |
Cluster of differentiation 80 (also CD80 and B7-1) is a protein found on dendritic cells, activated B cells and monocytes that provides a costimulatory signal necessary for T cell activation and survival. It is the ligan... | |||
TMPK-00179 | B7-1 Protein, Human, Recombinant (aa 35-242, His & Avi), Biotinylated | Human | HEK293 Cells |
Cluster of differentiation 80 (also CD80 and B7-1) is a protein found on dendritic cells, activated B cells and monocytes that provides a costimulatory signal necessary for T cell activation and survival. It is the ligan... | |||
TMPY-02964 | Calcineurin B/PPP3R1 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
PPP3R1 belongs to the calcineurin regulatory subunit family. It is a regulatory subunit of calcineurin. Calcineurin is composed of two subunits: calcineurin A (CnA) and calcineurin B (CnB). Dephosphorylation of the nucle... | |||
TMPJ-01441 | OX40L/TNFSF4 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells |
Tumor necrosis factor ligand superfamily member 4(TNFSF4/OX40L) is a single-pass type II membrane protein. OX40L is expressed by DCs, macrophages and B cells and signals via its cognate receptor OX40 which is mainly expr... | |||
TMPJ-00421 | CD27/TNFRSF7 Protein, Human, Recombinant (hFc & His) | Human | HEK293 Cells |
CD27 antigen is also known as CD27L receptor, T-cell activation antigen CD27, Tumor necrosis factor receptor superfamily member 7, T14 and TNFRSF7. In humans, it is encoded by the CD27 gene. CD27 is a single-pass type I ... | |||
TMPY-04461 | TRIB3 Protein, Human, Recombinant (GST) | Human | Baculovirus Insect Cells |
Tribbles homolog 3, also known as Neuronal cell death-inducible putative kinase, p65-interacting inhibitor of NF-kappa-B, SINK and TRIB3, is a Nucleus protein that belongs to the protein kinase superfamily and CAMK Ser/T... | |||
TMPJ-01096 | SLP-76 Protein, Human, Recombinant (His) | Human | E. coli |
Lymphocyte cytosolic protein 2(LCP2)contains a SAM domain and a SH2 domain. It is highly expressed in spleen, thymus and peripheral blood leukocytes, T-cell and monocytic cell lines, but expressed at lower level in B-cel... | |||
TMPJ-00770 | Granzyme B/GZMB Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
Granzyme B(GZMB) contains 1 peptidase S1 domain and belongs to the peptidase S1 family. This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp and seems to be linked to an... | |||
TMPH-02199 | TXNRD2 Protein, Human, Recombinant (His) | Human | E. coli |
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxide... | |||
TMPJ-01098 | PRDX4 Protein, Human, Recombinant (His) | Human | E. coli |
Peroxiredoxin-4 (PRDX4) is a member of the AhpC/TSA family. PRDX4 is a cytoplasmic protein and contains one thioredoxin domain. PRDX4 exists in homodimer or heterodimer with PRDX1. PRDX4 reduces hydrogen peroxide and alk... | |||
TMPJ-00110 | GITR/TNFRSF18 Protein, Mouse, Recombinant (hFc & His) | Mouse | HEK293 Cells |
Tumor necrosis factor receptor superfamily member 18(Gitr) contains 3 TNFR-Cys repeats and it have four isforms.IsformA、isformB and isformC is single-pass type I membrane protein and isformD is a secreted protein. The p... | |||
TMPK-00132 | GITR/TNFRSF18 Protein, Human, Recombinant (aa 26-161, His & Avi), Biotinylated | Human | HEK293 Cells |
GITR (glucocorticoid-induced tumor necrosis factor receptor), also known as AITR and TNFRSF18, is a 40 kDa transmembrane glycoprotein that functions in immune regulation.GIRT is a receptor for TNFSF18. Seems to be involv... | |||
TMPK-00133 | GITR/TNFRSF18 Protein, Human, Recombinant (aa 26-161, His) | Human | HEK293 Cells |
GITR (glucocorticoid-induced tumor necrosis factor receptor), also known as AITR and TNFRSF18, is a 40 kDa transmembrane glycoprotein that functions in immune regulation.GIRT is a receptor for TNFSF18. Seems to be involv... | |||
TMPJ-00803 | CD32B Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
Low affinity immunoglobulin gamma Fc region receptor II (CD32B) is a single-pass type I membrane protein and contains 2 Ig-like C2-type (immunoglobulin-like) domains. The inhibitory CD32B is expressed on B cells and mye... | |||
TMPY-04412 | Germinal Center Kinase/MAP4K2 Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells |
Mitogen-activated protein kinase kinase kinase kinase 2, also known as B lymphocyte serine/threonine-protein kinase, Germinal center kinase, MAPK/ERK kinase kinase kinase 2, MEK kinase kinase 2, Rab8-interacting protein,... | |||
TMPJ-00432 | GITR Ligand/TNFSF18 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells |
TNFSF18 is a single-pass type II membrane protein. It is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells. TNFSF18 cytokine binds to TNFRSF18/AITR/GITR. It regulates T-cell res... | |||
TMPY-01707 | CHST15 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Carbohydrate sulfotransferase 15, also known as N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase, GalNAc4S-6ST, B-cell RAG-associated gene protein, CHST15 and BRAG, is a single-pass type II membrane protein which ... | |||
TMPK-01086 | GITR/TNFRSF18 Protein, Mouse, Recombinant (aa 22-153, His) | Mouse | HEK293 Cells |
GITR (glucocorticoid-induced tumor necrosis factor receptor), also known as AITR and TNFRSF18, is a 40 kDa transmembrane glycoprotein that functions in immune regulation.GIRT is a receptor for TNFSF18. Seems to be involv... | |||
TMPK-01260 | GITR/TNFRSF18 Protein, Cynomolgus, Recombinant (aa 20-156, His) | Cynomolgus | HEK293 Cells |
GITR (glucocorticoid-induced tumor necrosis factor receptor), also known as AITR and TNFRSF18, is a 40 kDa transmembrane glycoprotein that functions in immune regulation.GIRT is a receptor for TNFSF18. Seems to be involv... | |||
TMPY-02252 | LAMTOR2 Protein, Human, Recombinant (His) | Human | E. coli |
Ragulator complex protein LAMTOR2, also known as Endosomal adaptor protein p14, Late endosomal/lysosomal Mp1-interacting protein, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2, Mitogen-activated protein-... | |||
TMPJ-00358 | DR6 Protein, Mouse, Recombinant (hFc & His) | Mouse | HEK293 Cells |
Tumor necrosis factor receptor superfamily member 21(DR6) is a single-pass type I membrane protein and contains 1 death domain and 4 TNFR-Cys repeats. The protein may activate NF-kappa-B and promote apoptosis and it may ... | |||
TMPJ-00329 | CD19 Protein, Rhesus macaque, Recombinant (hFc) | Rhesus | HEK293 Cells |
CD19 is a single-pass type I membrane protein containing 2 Ig-like C2-type (immunoglobulin-like) domains. CD19 is expressed on follicular dendritic cells and B cells. In fact, it is present on B cells from earliest recog... | |||
TMPY-04389 | MAP3K8 Protein, Human, Recombinant (GST) | Human | Baculovirus Insect Cells |
Mitogen-activated protein kinase kinase kinase 8, also known as Cancer Osaka thyroid oncogene, Proto-oncogene c-Cot, Serine/threonine-protein kinase cot, Tumor progression locus 2 and MAP3K8, is a cytoplasm protein that ... | |||
TMPJ-00455 | SLAMF5 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
CD84, also called SLAMF5, is a member of the CD2 subgroup of the immunoglobulin receptor superfamily. Members of this CD2 subgroup mediate signal transduction through the interaction of its immunoreceptor tyrosine-based ... | |||
TMPJ-00887 | NFKB1 Protein, Human, Recombinant (His) | Human | E. coli |
The 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radica... | |||
TMPJ-00934 | PRDX3 Protein, Human, Recombinant | Human | E. coli |
Thioredoxin-Dependent Peroxide Reductase Mitochondrial (PRDX3) is an enzyme that belongs to the AhpC/TSA family. Human and mouse PRDX3 genes are highly conserved, and they map to the regions syntenic between mouse and hu... | |||
TMPJ-00226 | SLAMF1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
Signaling lymphocyte activation molecule (SLAM), is a self-ligand glycoprotein which exists not only found on the surface of activated and memory T cells, but also on the surface of activated B cells, dendritic cells, an... | |||
TMPH-02876 | RIPK1 Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Serine-threonine kinase which is a key regulator of TNF-mediated apoptosis, necroptosis and inflammatory pathways. Exhibits kinase activity-dependent functions that regulate cell death and kinase-independent scaffold fun... | |||
TMPY-03999 | MD2/LY96 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
LY96 (Lymphocyte Antigen 96, also known as ESOP-1) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. This gene encodes a protein that associates with toll-like receptor 4 on the cell su... | |||
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Cat No. | Product Name | ||
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L1300 | PI3K-AKT-mTOR Compound Library | 420 compounds | |
A unique collection of 420 compounds targeting PI3K/Akt/mTOR signaling for research in PI3K/Akt/mTOR signaling, and drug discovery in diseases involved with PI3K/Akt/mTOR signaling; |